留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

空间小鼠实验有效载荷研究进展

李洁 刘方武 张涛

李洁, 刘方武, 张涛. 空间小鼠实验有效载荷研究进展[J]. 空间科学学报, 2021, 41(3): 445-456. doi: 10.11728/cjss2021.03.445
引用本文: 李洁, 刘方武, 张涛. 空间小鼠实验有效载荷研究进展[J]. 空间科学学报, 2021, 41(3): 445-456. doi: 10.11728/cjss2021.03.445
LI Jie, LIU Fangwu, ZHANG Tao. Research Progress of Space Mice Flight Payload[J]. Chinese Journal of Space Science, 2021, 41(3): 445-456. doi: 10.11728/cjss2021.03.445
Citation: LI Jie, LIU Fangwu, ZHANG Tao. Research Progress of Space Mice Flight Payload[J]. Chinese Journal of Space Science, 2021, 41(3): 445-456. doi: 10.11728/cjss2021.03.445

空间小鼠实验有效载荷研究进展

doi: 10.11728/cjss2021.03.445
基金项目: 

中国科学院空间科学战略性先导科技专项资助(XDA15013000)

详细信息
    作者简介:

    李洁,E-mail:lijie183@mails.ucas.ac.cn

  • 中图分类号: V524

Research Progress of Space Mice Flight Payload

  • 摘要: 啮齿动物是空间研究中常见的模型对象,已开展的空间生物实验中,小鼠表现出对飞行条件的有效适应.通过空间培养,研究者可对失重环境下小鼠的生理行为、骨骼和神经系统变化做进一步研究分析.本文对空间小鼠实验有效载荷的研究进展及其空间飞行实验进行了概述,为中国空间站上的小鼠培养箱设计提供参考.概述了地面小鼠培养技术和装置,为空间小鼠实验有效载荷设计提供地面对照;从实验研究内容和硬件系统设计两方面介绍了国际上已开展的空间小鼠实验,为中国空间生命科学研究和工程研制提供参考;对于中国发展空间小鼠实验有效载荷提出了建议.

     

  • [1] GUO Yinghua, LIU Changting. Research and prospect of space life science[J]. Med. J. Chin. People's Liberation Army, 2011, 36(4):416-417(郭英华, 刘长庭. 空间生命科学研究与展望[J]. 解放军医学杂志, 2011, 36(4):416-417)
    [2] TANG Zhangcheng. Research progress of space life science[J]. Bull. Chin. Acad. Sci., 1995, 2:128-133(汤章城. 空间生命科学研究进展[J]. 中国科学院院刊, 1995, 2:128-133)
    [3] BURGESS C, DUBBS C. Animals in Space: from Research Rockets to the Space Shuttle[M]. Berlin: Springer Science and Business Media, 2007
    [4] ANDREEV ANDRIEVSKIY A, POPOVA A, BOYLE R, et al. Mice in Bion-M 1 space mission: training and selection[J]. Plos One, 2014, 9:1-15
    [5] LIU Xinyong. Important support of biomedical scientific research-experimental animal[J]. Sci. Mosaic, 2002, 8:38(刘新勇. 生物医药科研的重要支撑—实验动物[J]. 科技广场, 2002, 8:38)
    [6] HE Mingzhong, TAN Yi, PAN Yongquan, et al. Study on the breeding and production of clean mice by using IVC cage[J]. J. Med. Pest Control, 2006, 10:80-82(何明忠, 谭毅, 潘永全, 等. 应用IVC笼具进行清洁小鼠繁育生产及动物实验探讨[J]. 医学动物防制, 10:80-82)
    [7] MO Meiying. The feeding and management of SPF experimental animals[J]. J. Guangdong Med. Univ., 2002, 20(1):68-69(莫梅英. SPF实验动物饲育与管理[J]. 广东医科大学学报, 2002, 20(1):68-69)
    [8] LI Meng, ZHANG Xin, LIU Wei, et al. Preliminary study on revision of national standard for experimental animal environment and facilities[J]. Chin. Pharmaceutical Affairs, 2013, 27(10):1037-1040(李萌, 张鑫, 刘巍, 等. 实验动物环境及设施国家标准修订初探[J]. 中国药事, 2013, 27(10):1037-1040)
    [9] ZHANG Zhenhan, CHENG Fuhua, YU Hongchuan. The effect of different temperature on energy metabolism in mice[J]. J. Agricul. Sci., 2007, 28(3):18-20(张振汉, 程富华, 于洪川. 不同温度对小鼠能量代谢的影响[J]. 农业科学研究, 2007, 28(3):18-20)
    [10] LIU Zhonghua, WEI Shelin. Cushions and cages for rodent laboratory animals[J]. Shanghai Laboratory Animal Sci., 2003, 23(3):182-185(刘忠华, 魏社林. 啮齿类实验动物的垫料和笼具[J]. 上海实验动物科学, 2003, 23(3):182-185)
    [11] WU Jianhua, REN Shuguang, JU Yingchao. Application of exhaust ventilation cage in barrier environment[J]. Prog. Veterinary Med., 2011, 11:139-140(吴建华, 任曙光, 巨英超. 排气通风笼具在屏障环境中的应用[J]. 动物医学进展, 2011, 11:139-140)
    [12] WU Teng, LIU Jinjing. Advantages of experimental animal welfare and IVC system on experimental animal welfare[C]//Annual Meeting of Experimental Animal Science and Technology in Northern China, 2015(吴腾, 刘晋津. 实验动物福利及IVC系统对实验动物福利的优势体现[C]//中国北方实验动物科技年会, 2015)
    [13] GUO Jian, ZHENG Zhenhui. Feeding of clean experimental animal cushions with corn cob as raw material[J]. Beijing Laboratory Animal Sci., 1992, 9(3):28-29, 54(郭健, 郑振辉. 应用以玉米芯为原料的清洁实验动物垫料饲养[J]. 北京实验动物科学, 1992, 9(3):28-29, 54)
    [14] LI Xiaojun, ZHANG Yinchun. Discussion on the factors affecting the quality of feed production in clean scale mice of experimental animals[J]. Chongqing J. Res. Chin. Drugs Herbs, 2006, 1:30-33(李小军, 张迎春. 浅谈影响实验动物清洁级大小鼠饲料生产品质的因素[J]. 重庆中草药研究, 2006, 1:30-33)
    [15] LIU Binghua. The relationship between experimental animals and animal experiments in biomedical research[J]. Sci. Technol. Consulting Guide, 2007, 27:DOI:CNKI: SUN:ZXDB.0.2007-27-092(刘冰花. 生物医学研究中实验动物和动物实验的关系[J]. 科技咨询导报, 2007, 27:DOI: CNKI:SUN:ZXDB.0.2007-27-092)
    [16] SU Weiwei, XU Jianjun. Analysis on the application status of experimental animals in biomedical research[J]. Zhongguo Xumu Shouyi Wenzhai, 2015, 11:48-48(苏玮玮, 许建军. 实验动物在生物医学研究中的应用现状分析[J]. 中国畜牧兽医文摘, 2015, 11:48-48)
    [17] WANG Zhaoqi, ZHANG Jingbo. Study on transgenic mice and its genetic significance[J]. Foreign Med. Genetic Sub-Book, 1987, 4:7-11(汪兆琦, 章静波. 转基因小鼠的研究及其遗传学意义[J]. 国外医学—遗传学分册, 1987, 4:7-11)
    [18] CUI Wei, ZENG Qiaoying. Antitumor Effect of Flavonoids from Saxifraga Tangutica Engl. on H22 Hepatoma Mice[EB/OL]. [2019-11-13]. https://doi.org/10.16656/j.issn.1673-4696.2020.0011(崔玮, 曾巧英. 甘青虎耳草黄酮对H22肝癌小鼠抗肿瘤作用的研究[EB/OL]. [2019-11-13].https://doi.org/10.16656/j.issn.1673-4696.2020.0011)
    [19] YANG Bing, YU Guihong, LI Mingyu, et al. Mechanism of flavonoid components in Astragali Radix in inhibiting tumor growth and immunoregulation in C57BL/6 tumor bearing mice based on “invigorating Qi for consolidation of exterior”[EB/OL]. [2019-11-13]. https://doi.org/10.19540/j.cnki.cjcmm.20191104.401
    [20] LONG Jie, YANG Zhigang. Humanized mouse model reconstructing human immune system and its application in study of blood system and its application in study of blood system diseases[J]. Laboratory Animal Sci., 2019, 36(4):86-92(龙杰, 杨志刚. 重建人类免疫系统的人源化小鼠模型及其在血液系统疾病研究中的应用[J]. 实验动物科学, 2019, 36(4):86-92)
    [21] YE Zhence, LI Yuan, HAN Yanjun, et al. Replication and identification of NOD/SCID immunodeficiency mouse models for leukemia[J]. J. Dali Univ., 2018, 3(08):96-100(叶振策, 李渊, 韩艳君, 等. NOD/SCID免疫缺陷小鼠白血病模型的复制及其鉴定[J]. 大理大学学报, 2018, 3(08):96-100)
    [22] YANG Chenghuan, YANG Yao, LI Kuo, et al. Placenta cellular and tissue changes after administration of phytohemagglutinin from red kidney bean for termination of middle-late pregnancy in mice[J]. Chin. J. Family Planning, 2015, 23(8):524-529(杨成焕, 杨姚, 李阔, 等. 红芸豆植物凝集素终止小鼠中晚期妊娠对胎盘组织的影响研究[J]. 中国计划生育学杂志, 2015, 23(8):524-529)
    [23] QI Ruxia, ZHANG Peng, YAO Xiaohong, et al. The effect of aqueous extract of kittul alabastrum on antifertility in female mice[J]. J. Jining Med. College, 2013, 36(4):253-255(齐汝霞, 张鹏, 姚晓红, 等. 棕榈花蕾水提物抗雌性小鼠生育作用[J]. 济宁医学院学报, 2013, 36(4):253-255)
    [24] TU Xumin, ZHENG Hui, ZHEN Rong, et al. Change of T-lymphocyte subsets,Th1 and Th2 after different doses of irradiation[J]. Teratogen. Carcin. Mut., 2012, 24(6):410-412, 417(涂序珉, 郑辉, 甄荣, 等. 不同辐射剂量损伤后T淋巴细胞亚群及Th1和Th2的变化[J]. 癌变畸变突变, 2012, 24(6):410-412, 417)
    [25] LIU Yamei, GUO Xingbo, KUANG Zhongsheng. Effect of Shugan Jianpi Bushen recipe on virology and liver histopathology of HBV transgenic mice[J]. J. New Chin. Medicine, 2011, 43(3):131-133(刘亚梅, 郭兴伯, 匡忠生. 疏肝健脾补肾方对HBV转基因小鼠病毒学及肝组织病理学的影响[J]. 新中医, 2011, 43(3):131-133)
    [26] CHENG Laying. Study on the application of transgenic animals in gerontology[J]. Asia-pacific Traditional Med., 2010, 6(10):6-7(程腊英. 转基因动物用于老年学的研究[J]. 亚太传统医药, 2010, 6(10):6-7)
    [27] WANG Weiwei, SONG Ledong, CHEN Jianjie. Effect of GanYanLing injection on liver histopathology and virology of HBV transgenic mice[J]. ZhongChengYao, 2009, 31(4):611-612(王维伟, 宋乐冬, 陈建杰. 肝炎灵注射液对HBV转基因小鼠肝组织病理及病毒学的影响[J]. 中成药, 31(4):611-612)
    [28] LI Yepeng, LI Yanjun, HAN Chunhui, et al. Study on immunorepressive mice model by gamma irradiation[J]. J. Hygiene Res., 2006, 1:100-102(李业鹏, 李燕俊, 韩春卉, 等. 小鼠放射性免疫低下模型的研究[J]. 卫生研究, 2006, 1:100-102)
    [29] Blogger: Stars of the Sea on the Road of the Garden. What Happened to the Animals that Were Sent into Space[OL]. [2018-10-28]. https://baijiahao.baidu.com/s?id=1615536346716795473&wfr=spider&for=pc
    [30] Blogger: Qingqing Said Game. What Happened to the Animals that Were Sent into Space: There's Only one Answer[OL]. [2018-04-03]. https://baijiahao.baidu.com/s?id=1596687408508029740&wfr=spider&for=pc
    [31] Blogger: Chen Ping Went to the Countryside. The Animals That Were Sent into Space for Experiments are They Alive Now[OL]. [2018-05-30]. https://www.sohu.com/a/233366663_100046826
    [32] Blogger: Yu Qing Technology. What happened to the animals that were sent into space. [OL]. [2018-10-09]. http://www.fxingw.com/fx/20181009/267261_2.html
    [33] Blogger: Retailer, One Elder Brother. What happened to the animals that were sent into space. [OL]. [2018-05-19]. https://www.sohu.com/a/232190871_596941
    [34] WANG Masha. Those years fly to the space of mice: ten thousand years supporting role, experience a narrow escape from death, the end is very sad. [OL]. [2018-11-28]. https://new.qq.com/cmsn/20181128/20181128003855.html
    [35] Xinhuanet. For the first time in the world//Development of mammalian embryos in space by shijian-10 satellite in China. [OL]. [2016-04-17]. https://www.guancha.cn/Science/2016_04_17_357309_s.shtml
    [36] RONCA A, FRITZSCH B, BRUCE L L, et al. Orbital spaceflight during pregnancy shapes function of mammalian vestibular system[J]. Behavioral Neurosci., 2008, 122(1):224
    [37] SHIBA D, MIZUNO H, YUMOTO A, et al. Development of new experimental platform ‘MARS’-multiple artificial-gravity research system-to elucidate the impacts of micro/partial gravity on mice[J]. Sci. Rep., 2017, 7(1): 10837
    [38] MOYER E L, DUMARS P M, SUN G S, et al. Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days)[J]. npj Microg., 2016, 2:16002
    [39] GARNER J P. Stereotypies and other abnormal repetitive behaviors: potential impact on validity, reliability, and replicability of scientific outcomes[J]. ILAR J., 2005, 46(2):106-117
    [40] JENNINGS R T, GARRIOTT O K, BOGOMOLOV V V, et al. The ISS flight of richard garriott: a template for medicine and science investigation on future spaceflight participant missions[J]. Aviation Space Environ. Med., 2010, 81(2):133-135
    [41] TOTH L A. The influence of the cage environment on rodent physiology and behavior: implications for reproducibility of pre-clinical rodent research[J]. Exp. Neurol., 2015, 270:72-77
    [42] BEHESHTI A, SHIRAZI FARD Y, CHOI S, et al. Exploring the effects of spaceflight on mouse physiology using the open access NASA genelab platform[J]. JoVE J. Visual. Exp., 2019, 143:e58447
    [43] MAINS R, LARENAS P, HING A M. A Researcher's guide to rodent research[R]//The NASA ISS Program Science Office, 2016:17-18
    [44] BHATTACHARYA S, BOWMAN R, DONOVAN F, et al. Developing new habitats for life science experiments on the international space station[J]. Dros. Inf. Serv., 2002, 85:156-168
    [45] CANCEDDA R, LIU Y, RUGGIU A, et al. The Mice Drawer System (MDS) experiment and the space endurance record-breaking mice[J]. PLoS One, 2012, 7(5): 32243
    [46] LIU Y, BITICCHI R, CILLI M, et al. Mouse Drawer System (MDS): an automated payload for supporting rodent research on the international space station[J]. Basic Appl. Myol., 2009, 87-95:2-3
    [47] RONCA A E, MOYER E L, TALYANSKY Y, et al. Behavior of mice aboard the international space station[J]. Sci. Rep., 2019, 9(1):4717
    [48] SHIMBO M, KUDO T, HAMADA M, et al. Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies[J]. Exp. Animals, 2016, 15: 0077
    [49] SANTUCCI D, KAWANO F, OHIRA T, et al. Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days[J]. PloS one, 2012, 7(7):40112
    [50] YUSUKE H, MAKOTO O, HIROAKI K, et al. Development of Mouse Habitat Unit for Use in “KIBO” Japanese Experiment Module on International Space Station[OL]. [2020-05-25]. https://www.mhi.co.jp/technology/review/pdf/e534/e534036.pdf
    [51] HAMILTON S A, PECAUT M J, GRIDLEY D S, et al. A murine model for bone loss from therapeutic and space-relevant sources of radiation[J]. J. Appl. Physiol., 2006, 101(3):789-793
    [52] NEUTELINGS T, NUSGENS B V, LIU Y, et al. Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice[J]. NPJ Microg., 2015, 1:15002
  • 加载中
计量
  • 文章访问数:  367
  • HTML全文浏览量:  58
  • PDF下载量:  40
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-11-18
  • 修回日期:  2020-05-25
  • 刊出日期:  2021-05-15

目录

    /

    返回文章
    返回