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Chinese Journal of Space Science ›› 2021, Vol. 41 ›› Issue (2): 293-300.doi: 10.11728/cjss2021.02.293

• Space Life Science and Microgravity Science • Previous Articles     Next Articles

Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis

YANG Chao1, XU Zihan1,2, LI Kai1, ZHANG Hongyu1, WANG Hailong1, WU Feng1, XU Zi3, DAI Zhongquan1,3, LI Yinghui1,2,3   

  1. 1 State Key Laboratory of Space Medicine Fundamentals and Application, Astronaut Center of China, Beijing 100094;
    2 School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001;
    3 Space Institute of Southern China, Shenzhen 518116
  • Received:2018-03-14 Revised:2019-08-22 Online:2021-03-15 Published:2021-04-10

Abstract: During the long-term space flight, the astronauts are in the confined weightlessness environment. However, the impact of confined environment on bone metabolism and glucose and lipid metabolism is not elucidated. In this paper, the changes of bone metabolism, glucose and lipid metabolism and their correlations through Space 180 CELSS System test of four volunteers were analyzed. Results showed that confined environment affected bone formation indices (BGP, PICP, BAP). Serum insulin level changed significantly during the test, and Lipid metabolism indicators have a downward trend. Correlation analysis showed that BGP was positively correlated with FRUC (r=0.525, p=0.001). There was also a significant positive correlation between BGP, CHOL and LDL (r=0.376, p=0.024; r=0.391, p=0.018). The results showed that the metabolism of bone and glycolipid was changed obviously in this experiment, and there was mutual regulation between them.

Key words: Hermetic space, Bone metabolism, Glycolipid metabolism

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