In this paper, with the observed critical frequencies of F2 layer at eight ionospheric observatories in Asia-Australic sector, the prediction ability of the NeQuick model on f0F2 over Asia-Australic sector were investigated. The agreement between the prediction by the NeQuick model and the observed f0F2 data in this sector is quite satisfactory. The model prediction error is bigger in the northern hemisphere than in the southern hemisphere, bigger in the years with high solar activity than in those with low solar activity, and in spring and autumn than in winter and summer. The RMSE is bigger in the years with high solar activity than in those with low solar activity.