Volume 35 Issue 3
May  2015
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WANG Jing, LAN Ding, WANG Yuren, DAI Guoliang, KONG Liming. Preliminary Studies on Collagen Fibrosis and Hydroxyapatite Crystallization under Microgravity[J]. Chinese Journal of Space Science, 2015, 35(3): 330-335. doi: 10.11728/cjss2015.03.330
Citation: WANG Jing, LAN Ding, WANG Yuren, DAI Guoliang, KONG Liming. Preliminary Studies on Collagen Fibrosis and Hydroxyapatite Crystallization under Microgravity[J]. Chinese Journal of Space Science, 2015, 35(3): 330-335. doi: 10.11728/cjss2015.03.330

Preliminary Studies on Collagen Fibrosis and Hydroxyapatite Crystallization under Microgravity

doi: 10.11728/cjss2015.03.330
  • Received Date: 2014-06-18
  • Rev Recd Date: 2015-01-04
  • Publish Date: 2015-05-15
  • Bone loss during long-term space flight is a serious problem. Collagen fibrils in bones are a key factor of Hydroxyapatite (HAP) crystal growth in its crystallization process, which is a main constituent of bones. In this paper, the changes of collagen fibrosis process under simulated microgravity and normal gravity conditions were studied, and the morphologies of HAP crystals grown on the surface of collagen fibrils were observed. Results showed that the amount and the size of pores inside collagen fibers formed under simulated microgravity condition and different concentrations of collagen were significantly larger than that under normal gravity condition and different concentrations of collagen. The distribution of the porosity under simulated microgravity condition was different with that under normal gravity condition. The morphology of HAP crystals under simulated microgravity condition was mainly cube-shaped. However, under normal gravity condition, HAP crystals were mainly plate-liked. These preliminary results will help to clarify the mechanism of bone loss in space in future.

     

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