Volume 38 Issue 4
Jul.  2018
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DAI Guoliang, LAN Ding, CHEN Jialu. Effect of Substrate and Flow Rate on Hydroxyapatite Growthormalsize[J]. Journal of Space Science, 2018, 38(4): 539-545. doi: 10.11728/cjss2018.04.539
Citation: DAI Guoliang, LAN Ding, CHEN Jialu. Effect of Substrate and Flow Rate on Hydroxyapatite Growthormalsize[J]. Journal of Space Science, 2018, 38(4): 539-545. doi: 10.11728/cjss2018.04.539

Effect of Substrate and Flow Rate on Hydroxyapatite Growthormalsize

doi: 10.11728/cjss2018.04.539
  • Received Date: 2017-08-22
  • Rev Recd Date: 2018-01-24
  • Publish Date: 2018-07-15
  • Hydroxyapatite (HAP) has excellent biocompatibility and bioactivity. Synthetic HAP can be widely used as medical and eco-friendly materials. In order to know valuable information of study and development of bone tissue engineering, the influence on HAP crystals growth by the changed of fluid field and the chosen of substrates are studied. The composites materials are used as substrates, which are made of Polydimethylsiloxane (PDMS)/HAP, PDMS/bioglass, and pure bioglass, respectively, and the effect of different substrates on HAP growth are analyzed. The results show that HAP crystals growth rates are different on different substrates when the flow rate is zero. HAP crystals growth rate is highest on PDMS/HAP substrate. However, it is lowest on pure bioglass substrate. Moreover, the influence of different flow rates of HAP growth solution (Simulated Body Fluid, SBF) by a homemade flow rate adjustment apparatus is studied. Three different flow rates, 10ml/min, 15ml/min, and 30ml/min, are used in this study. Under SBF flow conditions, the sizes of HAP crystals increased and the amount of amorphous precipitate decreased.


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  • [1]
    STAYTON P S, DROBNY G P, SHAW W J, et al. Molecular recognition at the protein-hydroxyapatite interface[J]. Crit. Rev. Oral Biol. M., 2003, 14(5):370-376
    MANN S. Biomineralization:Principles and concepts in bioinorganic materials chemistry[M]. London:Oxford University Press, 2001, 6-23
    MANN S, OZIN G A. Synthesis of inorganic materials with complex form[J]. Nature, 1996, 382(6859):313-318
    HEYWOOD B R, MANN S. Crystal recognition at inorganic-organic interfaces:nucleation and growth of oriented BaSO4 under compressed Langmuir monolayers[J]. Adv. Mater., 1992, 4(4):278-282
    MATSUMOTO T, OKAZAKI M, INOUE M, et al. Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid[J]. Biomaterials, 2002, 23(10):2241-2247
    LU H B, MA C L, CUI H, et al. Controlled crystallization of calcium phosphate under stearic acid monolayers[J]. J. Cryst. Growth, 1995, 155(1-2):120-125
    REN Wei, CAO Xianying, FENG Lingyun, et al. Methods of synthetic nanometer hydroxyapatite and modification of its surface[J]. J. Chin. Ceramic Soc., 2001, 1:38-43(任卫, 曹献英, 冯凌云, 等. 纳米羟基磷灰石合成及表面改性的途径与方法[J]. 硅酸盐通报, 2001, 1:38-43)
    REICH K M, GAY C V, FRANGOS J A. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production[J]. J Cell Physio, 1990, 143(1):100-104
    BAKKER A D, SOEJIMAL K, KLEIN-NULEND J, et al. The production of nitric oxide and prostaglandin E2 by primary bone cells is shear stress dependent[J]. J. Biomech, 2001,34, 671-677
    MULLENDER M, EL HAJ A J, YANG Y, et al. Mechanotransduction of bone cells in fluid shear stress rate dependent[J]. Bicochem. Biophys. Res. Commun., 2004, 315(4):823-829
    CHEN N X, RYDER K D, PAVALKO F M, et al. Ca2+ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts[J]. Am. J. Physiol. Cell Physiol., 2000, 278(5):C989-997
    HUO B, KANG YY, HU M, et al. Advances of mechanical stimulation induced calcium response and transfer in osteoblasts[J]. J. Med. Biomech., 2011, 26(4):382-388.
    BARAKAT A I, BARAKAT D K, GOJOVA A. secrets of the code:Do vascular endothelial cells use ion channels to decipher complex flow signal[J]. Biomaterials, 2006, 27(5):671-678
    DUAN Y R, ZHANG Z R, WANG C Y, et al. Dynamic study of calcium phosphate formation on porous HA/TCP ceramics[J]. J. Mater. Sci-Mater. M., 2005, 16, 795-801
    DENG Chunlin, CHEN Jiyong, FAN Hongsong, et al. Influence of Dynamic Flow Speed on Bonelike Apatite Formation in Porous Calcium Phosphate Ceramic in RSBF[J]. Key Eng. Mat. 2005, 288-289; 273-276
    OYANE A, KIM H M, FURUYA T, et al. Preparation and assessment of revised simulated body fluids[J]. J. Biomed. Mater. Res. A, 2002, 65A(2):188-195
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