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Chinese Journal of Space Science ›› 2021, Vol. 41 ›› Issue (1): 133-140.doi: 10.11728/cjss2021.01.133

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Research Progress of a Switch Gene in Response to Extreme Ionizing Radiation

LU Huizhi, HUA Yuejin   

  1. MOE Key Laboratory of Biosystems Homeostasis and Protection, Institute of Biophysics, College of Life Sciences, Zhejiang University, Hangzhou 310029
  • Received:2020-11-06 Online:2021-01-15 Published:2021-02-07

Abstract: Ionizing radiation exists widely in Earth and space, causing DNA damage and leading to mutation and even cell death. DNA damage response is essential for maintaining the integrity of genome. Deinococcus radiodurans is one of the model organisms for studying DNA damage repair due to its extraordinary DNA repair ability. PprI-DdrO system is a distinct and efficient damage response pathway in Deinococcus, in which PprI acts as an important switch regulating DNA damage response genes by cleavage of DdrO. This review discusses the research progresses of PprI from aspects of function, structure, activation mechanisms and applications.

Key words: PprI, Ionizing radiation, DNA damage response, Deinococcus radiodurans

CLC Number: