模拟失重(HDT—30°)和噪声复合因素对大鼠神经-内分泌-免疫功能的影响

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EFFECTS OF COMPOUND FACTORS OF SIMULATED WEIGHTLESSNESS (HDT-30°) AND NOISE ON THE NEUROENDOCRINE-IMMUNITY SYSTEM IN RATS

摘要: 本研究结果表明,大鼠在声级为85dB(A)噪声环境下悬吊(HDT-30°)10昼夜后,淋巴细胞转化率及白细胞介素2(IL2)明显降低,血浆皮质酮含量显着升高,下丘脑内多巴胺(DA)和去甲肾上腺素(NA)含量呈升高趋势,表明机体处于应激状态。单纯85dB(A)噪声组除多巴胺及T淋巴细胞增殖反应外上述指标也有同样的变化规律,但没有复台因素组明显。本文出现的神经-内分泌-免疫系统功能失调可能是航天员易患感染性疾病的原因之一。
- 模拟失重 /
- 噪声 /
- 神经递质 /
- 内分泌 /
- 免疫
Abstract: The results of the experiment show that the rats exposed to the suspension(HDT--30°) and the noise environment of 85 dB(A) for 10 days has a significantdecrease in lympocyte blastogenesis and interleukin--2 (IL2), a significant increase inthe content of plasma corticosterone, a tendency to be raised in the content of dopamine (DA) and noradrenaline (NA) in hypothalamus. These changes may be incoherence with stress alarm reaction. The indices mentioned above in the 85 dB(A)show a similar changes, but are less significant than that of the group which exposed to the noise and suspension. The function disturbance of the causes which makeastronauts suffering from infection diseases in space.
- Simulation weightlessness /
- Noise /
- Neurotransmitter endocrine /
- Immune /