EFFECT OF -6°HEAD-REST ON THE T LYMPHOCYTE AND ENDOCRINE SYSTEM
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摘要: 本文研究了-6°卧床模拟失重对T淋巴细胞受到有丝分裂原刺激后增殖能力和外周血总T淋巴细胞亚群(CD3+T细胞)、辅助/炎性T细胞亚群(CD4+T细胞)、杀伤T细胞亚群(CD8+T细胞)、及表达CD25分子细胞数的影响,同时观察生长激素、促肾上腺皮质激素、皮质激素的改变,来探讨免疫功能的变化与内分泌系统改变的关系.结果表明,模拟失重造成的免疫功能下降与内分泌系统紊乱有关.Abstract: This paper is to investigate the effects of the simulated weightlessness in a minus 6°head-down bed-rest condition(SW) on the T lymphocyte proliferation stimulated with PHA and on the T lymphocyte subsets.The changes of growth factor(GH), adrenocoticotrophic hormone(ACTH),cotisol(CT)are also observed.The results show that the T lymphocyte proliferation decreased significantly (P<0.05) two days after SW,and recover to normal six days after SW. The CD3, CD4, and CD8 positive T lymphocyte appeared no obvious depression after SW.The GH concentration in plasma increased significandy(P<0.01) two days after SW,and recover tO normal six days after SW.The ACTH concentration in plasma tend to increase tWo days after SW,it seem to decrease six days after SW.The CT concentration in plasma increase significantly(P<0.05) and recover to normal six days after SW.The conclusion is that the dysfunction of T lymphocyte may be caused by the perturbations of endocrine system.
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Key words:
- Simulated weightlessness /
- T lymphocyte subsets /
- Hormone /
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