微重力环境中哺乳动物细胞分子生物学效应研究进展

于洋; 王盛炜; 许召贤; 金明杰; 杨树林

doi:10.11728/cjss2018.06.891

微重力环境中哺乳动物细胞分子生物学效应研究进展

doi: 10.11728/cjss2018.06.891 cstr: 32142.14.cjss2018.06.891

南京理工大学环境与生物工程学院南京 210094

基金项目:

国家重大科学仪器设备开发专项项目资助（2012YQ0401400803）

详细信息

作者简介:

金明杰,E-mail:jinmingjie@njust.edu.cn;杨树林,E-mail:yshulin@njust.edu.cn

中图分类号: V527
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出版历程
- 收稿日期: 2017-09-11
- 修回日期: 2018-04-21
- 刊出日期: 2018-11-15

Advances on Molecular and Biological Effects of Mammalian Cells in Microgravity Environment

School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094

摘要

摘要: 随着载人航天事业的不断发展，空间失重环境引起的航天员健康问题（心血管疾病、免疫抑制、肌肉萎缩、骨质疏松等）日益突出，这已成为人类探索空间的一大阻碍.越来越多的研究关注到微重力条件下机体及细胞的变化.近期的研究表明，在细胞水平上，微重力会引起细胞降解，改变细胞骨架，并造成细胞在分子水平（如细胞增殖、分化、迁移、粘附、信号转导等过程）的一系列改变.本文对微重力条件下免疫细胞、内皮细胞、骨细胞、癌细胞的相关研究进行了归纳总结，研究结果可为微重力条件下机体及相关细胞的研究提供指导，为治疗或缓解微重力条件造成的疾病提供方法和思路.
- 微重力 /
- 细胞水平 /
- 基因表达 /
- 三维细胞聚集体
Abstract: With the continuous development of manned space program, astronaut health problems, such as cardiovascular diseases, immuno-suppression, muscle wasting, and osteoporosis, etc., caused by microgravity have attracted extensive concern, and these astronaut-derived health problems have become a major obstacle to the exploration of space. Many studies have focused on the changes of body and cell in microgravity conditions. Recent studies have shown that cell degradation and changes in the cytoskeleton can be induced by microgravity, and a series of changes caused by microgravity at molecular level were also found. In this paper, the recent studies on the behavior of immune cells, endothelial cells, bone cells and cancer cells in microgravity condition are reviewed. The results can provide instruction and reference for the further study of the disease occurrence in microgravity conditions, and provide some ideas for the treatment of diseases caused by microgravity conditions.
- Microgravity /
- Cellular level /
- Gene expression /
- Three dimensional cell aggregates

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参考文献(65)

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