头低位卧床对恒河猴骨代谢、糖脂代谢的抑制效应及其相关性分析

杨超; 徐子涵; 李铠; 张洪玉; 王海龙; 吴峰; 曹宏卿; 阚广捍; 李莹辉; 戴钟铨

doi:10.11728/cjss2020.04.540

头低位卧床对恒河猴骨代谢、糖脂代谢的抑制效应及其相关性分析

doi: 10.11728/cjss2020.04.540

杨超¹,
徐子涵^1,2,
李铠¹,
张洪玉¹,
王海龙¹,
吴峰¹,
曹宏卿¹,
阚广捍¹,
李莹辉^1,2, ,,
戴钟铨¹

1. 中国航天员科研训练中心航天医学基础与应用国家重点实验室北京 100094;
2. 哈尔滨工业大学生命科学与技术学院哈尔滨 150001

基金项目:

青年人才托举工程项目（2015-2017-2015QNRC001），国家自然科学基金项目（81801872，31470832，31570858），国家重大科学仪器设备开发专项（2013YQ190467）和中国航天员科研训练中心航天医学基础与应用国家重点实验室自主科研项目（SYFD1500604）共同资助

详细信息

作者简介:
杨超,E-mail:daizhq77@163.com.

通讯作者:
李莹辉,E-mail:yinghuidd@vip.sina.com

中图分类号: R85
计量
- 文章访问数: 975
- HTML全文浏览量: 94
- PDF下载量: 59
- 被引次数: 0
出版历程
- 收稿日期: 2018-03-14
- 修回日期: 2019-08-22
- 刊出日期: 2020-07-15

Inhibitory Effects of Head-down Bed Rest on Bone, Glycolipid Metabolism of Rhesus and Their Correlation Analysis

1 State Key Laboratory of Space Medicine Fundamentals and Application, Astronaut Center of China, Beijing 100094;
2 School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001

摘要

摘要: 空间失重引起的骨代谢调节失衡是航天员遭受的最严重的危害之一.骨代谢失衡还有可能影响机体的糖脂代谢平衡.本研究利用恒河猴头低位卧床模拟失重效应实验方法，分析头低位卧床过程中恒河猴血清中骨代谢、糖脂代谢指标变化情况及其相关性.卧床组恒河猴血清中BAP在头低位卧床实验开始7天便出现了显著下降（P<0.05），血清胰岛素、高密度脂肪酸含量在7天显著下降并一直维持在较低水平，血糖含量在7天时显著下降，但在21天时明显回升.分析发现，骨钙素与血糖、皮质醇、高密度脂肪酸含量间均存在相关性，这表明头低位卧床模拟失重效应实验中骨与糖脂代谢之间存在相互调控.
- 恒河猴 /
- 卧床实验 /
- 骨钙素 /
- 糖脂代谢
Abstract: Bone loss and subclinical diabetes-like are developed during long-term spaceflight. Recently, it was demonstrated that bone was able to regulate energy metabolism and testosterone synthesis via osteocalcin. In this study, we analyzed the changes of bone metabolism and glycolipid metabolism of rhesus and their association (P<0.05). Serum insulin and LDL content significantly decreased at 7 days and remained at a low level, and the blood glucose level showed a significant decline at 7 days, but recovery at 21 days. The correlation analysis showed that there was a correlation between osteocalcin and blood glucose, cortisol and HDL. The experimental results show that there is mutual regulation between bone and glycolipid metabolism in the bedrest experiment of rhesus.
- Rhesus /
- Bedrest /
- Osteocalcin /
- Glycolipid metabolism

HTML全文

参考文献(25)

[1]	TILTON F E. Long-term Follow-up of Skylab Bone Demineralization[R]. Alabama:Air Force Inst of Tech Wright-Patterson Afb Oh, 1979
[2]	VICO L, COLLET P, GUIGNANDON A, et al. Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts[J]. Lancet, 2000, 355(9215):1607-1611
[3]	LANG T F, LEBLANC A D, EVANS H J, et al. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight[J]. J. Bone Mineral Res., 2006, 21(8):1224-1230
[4]	CAILLOT-AUGUSSEAU A, LAFAGE-PROUST M H, SOLER C, et al. Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95)[J]. Clin. Chem., 1998, 44(3):578-585
[5]	CAILLOT-AUGUSSEAU A, VICO L, HEER M, et al. Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation:observations in two cosmonauts[J]. Clin. Chem., 2000, 46(8):1136-1143
[6]	ZERWEKH J E, RUML L A, GOTTSCHALK F, et al. The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects[J]. J. Bone Mineral Res., 1998, 13(10):1594-1601
[7]	LEE N K, SOWA H, HINOI E, et al. Endocrine regulation of energy metabolism by the skeleton[J]. Cell, 2007, 130(3):456-469
[8]	OURY F, SUMARA G, SUMARA O, et al. Endocrine regulation of male fertility by the skeleton[J]. Cell, 2011, 144(5):796-809
[9]	OURY F, KHRIMIAN L, DENNY C A. Maternal and offspring pools of osteocalcin influence brain development and functions[J]. Cell, 2013, 155(1):228-241
[10]	BELAVY D L, HIDES J A, WILSON S J, et al. Resistive simulated weightbearing exercise with whole body vibration reduces lumbar spine deconditioning in bed-rest[J]. Spine, 2008, 1(33):121-131
[11]	CAO PH, KIMURA SJ, BRANDON R, et al. Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest[J]. J. Appl. Physiol., 2005, 99(1):39-44
[12]	CONVERTINO VA, KOENIG SC, KROTOV VP, et al. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey[J]. Acta Astronaut., 1998, 42(1-8):255-263
[13]	FÖLDES I, KERN M, SZILÁGYI T, et al. Histology and histochemistry of intervertebral discs of rats participated in spaceflight[J]. Acta Biol. Hung., 1996, 47(1/2/3/4):145-156
[14]	SINHA R K, SHAH S A, HUME E L, et al. The effect of a 5-day space flight on the immature rat spine[J]. Spine, 2002, 2(4):239-243
[15]	YASUOKA H, ASAZUMA T, NAKANISHI K, et al. Effects of reloading after simulated microgravity on proteoglycan metabolism in the nucleus pulposus and anulus fibrosus of the lumbar intervertebral disc:an experimental study using a rat tail suspension model[J]. Spine, 2007, 32(25):734-740
[16]	CONVERTINO V A, KOENIG S C, KROTOV V P, et al. Effects of 12 days exposure to simulated microgravity on central circulatory hemodynamics in the rhesus monkey[J]. Acta Astron., 1998, 42(1/2/3/4/5/6/7/8):255-263
[17]	SUN B, ZHANG X Y, LIU L Z, et al. Effects of head-down tilt on nerve conduction in rhesus monkeys[J]. Chin. Med. J., 2017, 130(3):323
[18]	ARMBRECHT G, BELAVY D L, GAST U, et al. Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest:biochemical markers of bone metabolism[J]. Osteoporos. Int., 2010, 21(4):597-607
[19]	KIM H, IWASAKI K, MIYAKE T, et al. Changes in bone turnover markers during 14-day 6 degrees head-down bed rest[J]. J. Bone. Mineral Res., 2003, 21(5):331-335
[20]	LUEKEN S A, ARNAUD S B, TAYLOR A K, et al. Changes in markers of bone formation and resorption in a bed rest model of weightlessness[J]. J. Bone Mineral Res., 1993, 8(12):1433-1438
[21]	YANG C, CHEN J, WU F, et al. Effects of 60-day head-down bed rest on osteocalcin, glycolipid metabolism and their association with or without resistance training[J]. Clin. Endocrinol., 2014, 81(5):671-678
[22]	BROOKS N E, CADENA S M, CLOUTIER G, et al. Influence of exercise on the metabolic profile caused by 28 days of bed rest with energy deficit and amino acid supplementation in healthy men[J]. Int. J. Med. Sci., 2014, 11(12):1248-1248
[23]	LEACH C S, JOHNSON J P, KRAUHS J M. et al. Cholesterol in serum lipoprotein fractions after spaceflight[J]. Aviat. Space Environ. Med., 1988, 59(11):1034-1037
[24]	SIMPSON E J, DEBEVEC T, EIKEN O, et al. Analogs of microgravity:space research without leaving the planet:PlanHab:the combined and separate effects of 16 days of bed rest and normobaric hypoxic confinement on circulating lipids and indices of insulin sensitivity in healthy men[J]. J. Appl. Physiol., 2016, 120(8):947
[25]	BIOLO G, DI GIROLAMO F G, MCDONNELL A, et al. Effect of hypoxia and bed rest on markers of cardiometabolic risk:compensatory changes in circulating trail and gluthione rebox capacity[J]. Front. Physiol., 2018, 9:1000