Mirror-image Biological Molecules
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摘要: 生物分子的手性均一性是地球上生命的重要标志.生命对D型核糖和L型氨基酸的依赖究竟是生命起源的必然，还是早期地球上发生的一次偶然事件，目前尚无定论.地球上生命手性均一性的原因还未能被很好地解释，但一些实验证据已显示基于L型核糖和D型氨基酸的镜像生命被合成出来的可能性.本文简要总结了当前对镜像生物分子的研究进展和方向，并探讨了在实验室中运用新型镜像分子生物学工具构建镜像生命的可行性.Abstract: The homochirality of biological molecules is a hallmark of all terrestrial life. Whether life's dependence on D-ribose nucleic acids and L-amino acids was required for the origins of life, or merely a chance event on prebiotic Earth remains unclear. Despite the challenges in elucidating the cause for homochirality, accumulating evidence suggests the possibility of synthesizing mirror-image life based on L-ribose nucleic acids and D-amino acids. Here we briefly summarize the recent findings in mirror-image biology and discuss the prospects of building mirror-image life in the laboratory using newly developed mirror-image molecular tools.
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Key words:
- Origins of life /
- Homochirality /
- Mirror-image life /
- Astrobiology
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