Abstract: Aiming at the difficulties in system of system (SOS) design and interface verification in lunar exploration engineering, in order to effectively solve the pre-validation problems of requirements, functions and interfaces, under the conditions of adaptive tailoring and combination for Unified Architecture Framework (UAF), the method of design and modeling for lunar exploration engineering based on UAF is proposed. The key links in each phases of lunar exploration are analyzed, the view models based on strategic, operational and resources viewpoint are established, the models are optimized through requirements traceability and logical simulation iterative validation, this method improves the rationality and effectiveness of design and modeling, it provides a feasible reference for the SOS design of lunar exploration engineering.