Volume 43 Issue 5
Nov.  2023
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Article Navigation >  Chinese Journal of Space Science  > 2023  >  43(5): 907-915 Open Access
CHEN Sisi, ZHANG Xi, ZHENG Gu, WANG Qingying, DING Xuewen, CHEN Yulei, SHU Yaogen. Study on Spaceflight-associated Neuro-ocular Syndrome with the Rat Tail Suspension by ULOCT and UHROCT (in Chinese). Chinese Journal of Space Science, 2023, 43(5): 907-915 doi: 10.11728/cjss2023.05.2023-05-yg11
Citation: CHEN Sisi, ZHANG Xi, ZHENG Gu, WANG Qingying, DING Xuewen, CHEN Yulei, SHU Yaogen. Study on Spaceflight-associated Neuro-ocular Syndrome with the Rat Tail Suspension by ULOCT and UHROCT (in Chinese). Chinese Journal of Space Science, 2023, 43(5): 907-915 doi: 10.11728/cjss2023.05.2023-05-yg11
shu

Study on Spaceflight-associated Neuro-ocular Syndrome with the Rat Tail Suspension by ULOCT and UHROCT

doi: 10.11728/cjss2023.05.2023-05-yg11 cstr: 32142.14.cjss2023.05.2023-05-yg11
  • 1.

    Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001

  • 2.

    Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027

  • 3.

    Research Center of Quantitative Detection Technology, NMPA Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, Wenzhou 325001

  • 4.

    Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325024

  • Received Date: 2023-08-07
  • Rev Recd Date: 2023-09-01
    • Available Online: 2023-10-11
    Abstract
  • To investigate the correlation between the relevant characteristic parameters of Spaceflight-Associated Neuro-ocular Syndrome (SANS) and microgravity, Sprague-Dawley (SD) rats with a tail-suspended animal model were utilized. Ultra-Long Scan Depth Optical Coherence Tomography (ULOCT) system was set up to measure the characteristic parameters of the rat eyes (corneal thickness, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length), and an Ultra-High-Resolution Optical Coherence Tomography (UHROCT) system to measure the sublayer structural parameters of the rat fundus (retinal nerve layer, inner retinal layer, outer retinal layer, choroid, and sclera thickness). The results came from the fundus photographs showed that there were no obvious symptoms of optic disc edema. However, the results came from ULOCT and UHROCT showed the significant changes in the rat eye structure: corneal thinning (p<0.01), axial shortening (p<0.05), and outer retinal thinning (p<0.01). These changes of characteristic parameters, especially the significant axial shortening, exhibited subclinical symptoms of SANS. This study provides a macroscopic animal model and a novel in vivo ocular measurement method for investigating the molecular mechanisms of SANS at the microscopic level in future researches.

     

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