The responses of thermospheric winds at middle latitudes to the moderate geomagnetic storm of Mar 18-19, 2018, are examined using two ground-based Fabry-Perot Interferometer (FPI) observations from the Xinglong (XLON, 40.2°N, 117.6°E; magnetic latitude: 35°N) and the Sutherland Astronomical Observatory (SAAO, 32.2°S, 20.48°E; magnetic latitude: 40.7°S), combined with simulations from the Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIEGCM). The results reveal that the response of thermospheric winds to the geomagnetic storm is more pronounced in the Southern Hemisphere than in the Northern Hemisphere. Significant enhancements in equatorward and westward winds are observed at the SAAO station, with maximum meridional wind speeds reaching 128.4 m/s (equatorward) and maximum zonal wind speeds reaching -165.6 m/s (westward). Comparative analysis with TIEGCM simulations indicates that the model can reasonably reproduce the disturbance trends in observations, particularly in the variations of meridional winds at SAAO and zonal winds at XLON. However, certain quantitative discrepancies remain in the model's predictions: the model underestimates the eastward zonal winds at SAAO and overestimates the equatorward meridional winds at XLON.