Space Radiation-induced Impacts on Gut Flora, Metabolites and Multisystem Diseases

WU Zhujun; ZHANG Xin; PANG Yudi; DENG Yulin; WANG Zhimin

doi:10.11728/cjss2024.05.2023-0126

Volume 44 Issue 5

Oct. 2024

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Article Navigation > Chinese Journal of Space Science > 2024 > 44(5): 873-883 Open Access

WU Zhujun, ZHANG Xin, PANG Yudi, DENG Yulin, WANG Zhimin. Space Radiation-induced Impacts on Gut Flora, Metabolites and Multisystem Diseases (in Chinese). Chinese Journal of Space Science, 2024, 44(5): 873-883 doi: 10.11728/cjss2024.05.2023-0126

Citation:

WU Zhujun, ZHANG Xin, PANG Yudi, DENG Yulin, WANG Zhimin. Space Radiation-induced Impacts on Gut Flora, Metabolites and Multisystem Diseases (in Chinese). Chinese Journal of Space Science, 2024, 44(5): 873-883 doi: 10.11728/cjss2024.05.2023-0126

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Space Radiation-induced Impacts on Gut Flora, Metabolites and Multisystem Diseases

doi: 10.11728/cjss2024.05.2023-0126 cstr: 32142.14.cjss2024.05.2023-0126

WU Zhujun^1
,,
ZHANG Xin^{1, 共
,},
PANG Yudi¹,
DENG Yulin²,
WANG Zhimin^{1, 2
,
,}

1.
Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing 100081
2.
School of Medical Technology, Beijing Institute of Technology, Beijing 100081

Received Date: 2023-11-12
Rev Recd Date: 2024-01-10

Available Online: 2024-02-26

Abstract

Abstract

Maintaining the homeostasis of gut flora is of great significance to protecting human health. Gut flora plays a key role in regulating body functions, such as digestion, metabolism, immunity, and cognition. These physiological functions often depend on the diversity of gut flora, the stability of the bacterial flora structure, and the balance of the microecology. In the outer space, astronauts face many special environmental factors including the space radiation. Space radiation can cause imbalance of gut flora and changes in metabolites, damaging the intestinal barrier function, and further lead to pathological injury to multiple systems such as the intestine, cardiovascular, brain, and lungs. This paper reviews the characteristic changes in gut flora homeostasis and its metabolites under space flight or simulated space radiation, as well as the interaction between gut flora and intestinal damage and other multi-system diseases under radiation effects. It is expected to provide a reference for the further study of the pathological mechanisms upon space radiation and radiation protection measures.
- Space radiation,
- Gut flora,
- Microbial metabolites,
- Radiation injuries,
- Multisystem diseases

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References(92)

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