Volume 45 Issue 2
Apr.  2025
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Article Navigation >  Chinese Journal of Space Science  > 2025  >  45(2): 477-492 Open Access
WEI Dongping, SUN Lianwen, YANG Xiao. Applications of Microfluidic Chips in Space Life Sciences (in Chinese). Chinese Journal of Space Science, 2025, 45(2): 477-492 doi: 10.11728/cjss2025.02.2024-0155
Citation: WEI Dongping, SUN Lianwen, YANG Xiao. Applications of Microfluidic Chips in Space Life Sciences (in Chinese). Chinese Journal of Space Science, 2025, 45(2): 477-492 doi: 10.11728/cjss2025.02.2024-0155
shu

Applications of Microfluidic Chips in Space Life Sciences

doi: 10.11728/cjss2025.02.2024-0155 cstr: 32142.14.cjss.2024-0155

  • Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing 100191

  • Received Date: 2024-11-02
  • Rev Recd Date: 2025-01-11
    • Available Online: 2025-03-11
    Abstract
  • Microfluidic chip, also known as Lab-on-a-Chip (LOC), represent a cutting-edge technology that enables the precise manipulation of small volumes of liquid at the microscale. In recent years, this innovative technology has garnered significant attention for its potential to revolutionize life science research in vitro. Particularly in the fields of drug screening and in vitro diagnostics, microfluidic chips offer remarkable advantages, including high throughput and high sensitivity, allowing for the rapid and accurate analysis of large numbers of samples. Moreover, these chips can be engineered to simulate the complex microstructures, microenvironments, and physiological functions of specific human organs, providing researchers with a powerful tool to study biological processes in a controlled and highly specific manner. Characterized by their compact size, minimal sample consumption, short analysis times, and low power requirements, microfluidic chips are especially well-suited for space science experiments, where resources are often limited and environmental conditions are highly complex. In space research, animal models may exhibit significant individual differences, and single-cell models often fail to accurately simulate the complex in vivo environment. Microfluidic chips effectively address these limitations by offering a more controlled and representative experimental platform. They can simulate the physiological conditions of human organs with greater accuracy and reliability compared to traditional models, making them an invaluable tool for space life science research. This article provides an overview of the development history, fabrication technology, and fluid loading methods of microfluidic chips. It traces the evolution from early concepts to today’s complex devices, discusses various fabrication techniques with their respective advantages and application scenarios, and explores loading techniques that ensure precise fluid control within the chip. Beyond these, the article also highlights the application of microfluidic chips in both terrestrial and space life sciences. From the aspects of drug screening, in vitro diagnostics, and organ-on-a-chip, it focused on how chips can advance life science research. In the context of space research, the article discusses how chips can be utilized to study the effects of microgravity on cell behavior, tissue development, and other biological phenomena. It provides a comprehensive reference for the broader application of microfluidic chips in space life science research.

     

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